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Changing Perceptions Tour

METABOLON is an art installation created by artist Seiko Kinoshita and scientist Dr Nate Adams, originally commissioned for Festival of the Mind 2016. It is based on the research performed by Nate and his colleagues from the laboratory of Professor Neil Hunter FRS, in the department of Molecular Biology and Biotechnology at the University of Sheffield.

After their first successful art and science collaboration, the giant GFP Origami for Krebs Festival in 2015, Seiko and Nate continued their conversations and developed the artistic concept and design of METABOLON. On gaining funding from Arts Council England, The University of Sheffield, and the BBSRC, they created the beautiful physical installation with artist Darren Richardson.

In 2018, Seiko and Nate secured further funding from Arts Council England and The University of Sheffield to tour METABOLON and their new work Aegis to 20-21 Visual Arts Centre (27/10/2018 - 7/1/2019), The Hartlepool Art Gallery (19/1/2019 - 16/3/2019) and Manchester Central Library (tbc in 2020).

In this touring exhibition, they have created art installations to explore the invisible nano world that Nate researches in the lab, hoping to change peoples’ perceptions towards both Art & Science which are often seen as incompatible subjects.


The Story



To make the green pigment chlorophyll, many complex chemical reactions must occur, accelerated and protected by enzymes. The colourful molecules produced during this process are toxic and must be shuttled safely from one enzyme to the next to prevent damage to the cell. To ensure the fast progression of all these steps, the enzymes are physically located near to each other at a something called a membrane, a surface and barrier within a cell.

While research involves a world of data, equations and graphs, often scientists have a virtual or cartoon representation of their work in their mind‘s eye. Science involves a lot of imagination, but ideas are communicated in text; scientists write essays which discuss their experimental results and theories. METABOLON is research as contemporary art. While Seiko has used experimental results as a starting vision, using her intricate craft skills she has created a unique aesthetic to produce an artistic interpretation of the chlorophyll biosynthesis pathway. Seiko has taken inspiration from the ‘standard’ membrane model, taught in biology textbooks, but has also rotated it 90 degrees so that you may explore the work at a more intimate level.

Science is a physically demanding practise, requiring meticulous repetitive experiments to build a complete story. Seiko mimics this in her artistic practise. Particularly using traditional hand craft skills, here folding over 6000 pieces of paper 84,000 times over a three months period. She hopes by visualising this repetitive process, people can feel the effort going into the experimental process required by science. The steel sculptures are inspired by the intricate three dimensional structures of the proteins, and hand welded by sculptor Darren Richardson.


Enzymes are able to perform chemical reactions at room temperature and in an environment filled with water. Many equivalent reactions performed in a laboratory by scientists need lots of energy - needing high temperatures, pressures and toxic solvents.

One way that enzymes are able to skirt the high energy requirements found in the lab is by providing the perfect three dimensional environment, positioning all the components of a reaction in the optimal physical space. Then it only requires a small amount of energy to push a reaction over to completion. In addition, enzymes provide protection to the newly formed molecules to prevent unwanted and potentially dangerous side reactions occurring.

The pigments created in the sequence of reactions leading to chlorophyll absorb lots of light energy. Energy is never lost, it is just converted into other forms, such as heat, which within a cell can be very dangerous. To help prevent the newly formed pigments from causing damage, they are held within the protecting embrace of enzymes and proteins, which have systems in place to absorb and safely disperse destructive energy.

Aegis depicts this protecting embrace. Seiko found this protective natural structure reminiscent of a baby in its mother’s womb, and has reflected this delicate quality into this work. The helical structures of the enzyme encase the porphyrin molecule (seen right), producing the environment that assists the reaction and protects the cell from damage.

The helical structures are made with paper yarn which is hand dyed and woven on a traditional hundred year old Dobby Loom. The steel porphyrin pigment is protoporphyrin IX. Here it is about to receive an ion of magnesium in it’s very centre, this is the first step of seven chemical reactions assisted by enzymes which ultimately leads to chlorophyll.

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How small is small? The chemical reactions of life occur at the nanometre scale (10^-9 metres). METABOLON and Aegis explore the invisible nano-world that exists within the cells of a leaf from a plant. The sculptures you see are around 50 million times bigger than real life.

The molecule of chlorophyll shown here measures 2 nanometres across, or 0.000,000,002 metres.    


METABOLON & Aegis are on show at Hartlepool Art Gallery 19 January - 16 March 2019

Hartlepool Art Gallery
Church Street, Hartlepool TS24 7EQ

Open Tuesday - Saturday 10:00 - 17:00
The METABOLON: Changing Perceptions Tour is free

Workshops and Tours

As part of British Science and Engineering Week, we are holding a series of schools and family workshops, and a special evening event where you can see METABOLON and Aegis 'in the dark'.

Schools Workshops

Friday 8 March 2019
KS2    9.30 - 10.45
KS3    11.00 - 12.15
KS4    13.00 - 15.20

Activities include origami, exploring
enzymes & shape, charge, function and using microscopes.

Book direct via email: Caroline.Shilson@hartlepool.gov.uk

Night time tour

Friday 8 March 2019
17.30 - 20.00

A unique oppotunity to see METABOLON & Aegis at night. We dimm the lights to reveal the full grandure of the art-works. Nate will discuss how the works relate to cutting edge science, and Seiko will explore how she intepretes scientific data in craft form.

Sign up at the Facebook event.

Family Drop-in

Saturday 9 March 2019
10.00 - 14.00

Come and meet Seiko, Nate and his team of scientist. Learn how to make your own origami, build 3D paper models of proteins and explore the world around you using microscopes. No need to book, just drop in - for more information contact Hartlepool Art Gallery.

See more at the Facebook event.


Nate Adams
The University of Sheffield,
Firth Court,
Western Bank,
Sheffield S10 2TN

METABOLON: Changing Perceptions tour is supported by